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KMID : 0811820070110020161
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Journal of Korean Society of Pediatric Nephrology
2007 Volume.11 No. 2 p.161 ~ p.167
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The Clinical Usefulness of Cystatin C in Evaluating Renal Function in Children with Various Renal Diseases
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Kim Khi-Joo
Kim Jeong-A
Shin Jae-Il
Hwang You-Sik
Jeong Il-Cheon
Lee Jae-Seung
Lim Jong-Baeck
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Abstract
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Purpose : GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C.
Methods : We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 : CrCl <40 mL/min/1.73m2, Group 2 : CrCl 40-60 mL/min/1.73m2, Group 3 : CrCl >60 mL/min/1.73 m2). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them.
Results : Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 : 100% vs. 100%, Group 2 : 70% vs. 35%, Group 3 : 46% vs. 15%).
Conclusion : Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases.
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KEYWORD
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Glomerular filtration rate, Cystatin C, Creatinine, Creatinine Clearance
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